Metformin has been used for decades as a first-line drug for treating type 2 diabetes. It lowers blood glucose levels by inhibiting glucose production in the liver, and also improves glucose uptake and use by muscle tissue. Yet until now, exactly how the drug works to increase glucose uptake in muscle tissue has been unknown. Now researchers think they have new insight into the drug’s mechanism of action, which could lead to new indications for its use and new pharmaceutical developments. Read more