Drugs

Study Says Best Drug Combo for Type 2 Kids Is Metformin and Rosiglitazone

While the study by researchers at George Washington University and the University of Colorado shows that a combination therapy is more effective, the inclusion of rosiglitazone raises some concerns.

Study identifies apolipoprotein as target for diabetes drug

New research from the University of Cincinnati (UC) points to the naturally produced protein apolipoprotein A-IV (apoA-IV) as a potential target for a new diabetes therapeutic.

Diabetes patients at risk from medication mistakes

Nearly one in three hospital patients with diabetes are affected by medication mistakes that can lead to dangerously high or low blood glucose levels, checks have revealed.

FDA Warns Diabetes Patients About Combining Aliskiren

On April 19, the US Food and Drug Administration issued a warning to diabetes patients not to combine the blood pressure medication aliskiren (Tekturna) with ACE inhibitors or angiotensin receptor blockers.

Statins and Diabetes: Joslin Doctor Responds to Controversy

Allison Goldfine, M.D., Section of Clinical, Behavioral & Outcomes Research at Joslin Diabetes Center, is responding to the controversy in her editorial titled “Statins: Is It Really Time to Reassess Benefits and Risks?”

Takeda’s Type 2 Diabetes Therapies Set Back Again by FDA

Takeda Pharmaceutical received a complete response letter from the FDA regarding alogliptin and fixed-dose combination (FDC) alogliptin and pioglitazone in type 2 diabetes.

Public Citizen wants withdrawal of diabetes drug

A consumer advocacy group is calling on government regulators to withdraw a diabetes drug from Novo Nordisk, saying the injectable medication raises the risk of thyroid cancer, pancreatitis and kidney failure.

Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned

It’s not clear whether patients with type 2 diabetes gain any long-term benefit from taking the blood sugar-lowering drug metformin and insulin together rather than insulin alone.

New study examines risks and benefits Metmorfin

A study suggests that the long-term benefits of this drug compared with the risks are not clearly established.

Victoza Superior To Januvia In Blood Sugar And Body Weight Control

Diabetes drug Victoza (liraglutide [rDNA] injection) has been shown to be superior to Januvia (sitagliptin) in achieving body weight reduction and blood sugar control, Novo Nordisk has announced.

Weekly Drug May Substitute for Pre-Meal Insulin

Albiglutide, a once-weekly formulation of a glucagon-like peptide-1 agonist, appears to be effective at controlling blood sugar compared with insulin, according to a release from GlaxoSmithKline.

Sulfonylureas in Diabetes: Why So Controversial?

Sulfonylureas have been used to treat type 2 diabetes for many, many years. However, newer agents and a better understanding of type 2 diabetes have called their role into question.

GSK says new data support filing of diabetes drug

GlaxoSmithKline plans to push ahead with plans to file its experimental once-weekly diabetes drug albiglutide for regulatory approval, following the read-out from a series of clinical trials.

Aspirin enhances platelet isoprostanes in type 2 diabetes

For patients with type 2 diabetes mellitus who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March 16 in Diabetes.

Blood-Pressure Drug May Slow Diabetes Progression

Common high-blood-pressure medication appears to reverse the diabetes-related death of pancreatic beta cells, according to a University of Alabama at Birmingham study published March 22 in the journal Diabetes.

Diabetes Prevention With Metformin Is Safe, Well-Tolerated

Long-term treatment with metformin is safe for preventing or delaying the development of type 2 diabetes, according to an article published in the April issue of Diabetes Care.

Positive Results on Drug to Treat Diabetic Macular Edema

Conducted at St. Michael Hospital in Toronto Canada, the trial explored the safety and efficacy of twice-daily oral doses of Optina(TM), to reduce macular edema as determined by OCT (optical coherence tomography).

TAK-875 controls blood sugar, reduces hypoglycemia risk

An experimental diabetes drug, TAK-875, demonstrated its ability to improve blood-sugar control with a low risk of hypoglycemia, according to phase 2 study results published online February 27 in The Lancet.


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Metformin, the marvellous survivor

Metformin was first formulated in 1922. But unlike many drugs of the same era which have fallen by the wayside, it has endured, or indeed, thrived. What is so great about the #1 most prescribed diabetic drug?

First allosteric insulin receptor-activating antibody to improve glycemic control in vivo

XOMA Corporation (Nasdaq: XOMA) announced that its study of XMetA, the company’s fully-human allosteric monoclonal antibody to the insulin receptor, is available online and will be published in the May issue of the American Diabetes Association’s journal Diabetes.


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